Exendin-4 is similar to a hormone found in humans called GLP-1, which is released after eating and is important for controlling blood sugar levels in humans
However, it has side effects
A narrative review concluded that the practice is controversial because there are no standardized dosing protocols and nearly onethird of patients report adverse effects, ranging from mild gastrointestinal symptoms to liver dysfunction and lifethreatening allergic reactions
Community protocols describe 250-500 mcg subcutaneous daily, near-umbilical for GI-targeted effect, over 4-6 weeks during dose escalation
GLP-1 therapy is also proven for: semaglutide for PCOS weight management, GLP-1 for visceral fat and belly fat reduction, GLP-1 for cravings and emotional eating, hormone-related weight gain, GLP-1 for osteoarthritis joint relief, semaglutide heart and cardiovascular protection, weight loss for cholesterol improvement, and GLP-1 muscle loss prevention with proper protocol
Compared to other medications, semaglutide has been found to be more effective for weight loss than liraglutide ( Saxenda ), though not as effective as tirzepatide (Zepbound)