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These studies, while bearing inherent observational study constraints including potential confounding and enrollment bias, offer valuable complementary evidence regarding major adverse liver outcomes (MALOs) in real-world clinical practice

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Antioxidant and anti-inflammatory effects of IGF-I have been documented to reduce atherosclerotic burden, mainly both via cytokine response modulation (attenuating IL-6 and TNF- pro-inflammatory responses)[299] and/or eNOS activity regulation[295]

PtdIns-4,5-P 2 ], phosphatidylinositol-3,4-bisphosphate [PtsIns-3,4-P 2 ], and phosphatidylinositol-1,4,5-trisphosphate [PIP 3