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However, the negative redox potential of roGFP2, the instantaneous nonenzymatic formation of roGFP2(S 2 ) from roGFP2(SSG), and the very slow nonenzymatic reaction of roGFP2(S 2 ) with GSH make the nonenzymatic shortcut from Fig

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In order to capture this complexity, we have, in collaboration with clinicians and experimentalists, developed mathematical models based on the real underlying physiology [10-16]

3), which affords the possibility to monitor more reliably in situations where pH can respond readily to environmental changes, for example in the yeast cytosol 46

This gap in evidence can lead to the execution of unproven treatments worldwide, posing potential risks to patients