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In an autocrine mechanism, SASP factors reinforce the cellular senescence of the senescent cells themselves, while in a paracrine mechanism, they are responsible for inducing senescence in surrounding cells [35]
The vast majority of data comes from in vivo studies conducted on murine and rat models, as well as in vitro experiments on cell cultures
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It can sense biochemical changes and act as a paracrine regulator of cardiomyocyte function, secreting nitric oxide (NO), endothelin, and prostacyclin [26]
