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A notable RCT is the pioglitazone in early PD trial, which failed to demonstrate the possibility of pioglitazone delaying disease progression in early-stage PD patients [38]
Based on these data, across all studies, few participants received rescue therapy (ranging approximately between 0.3% and 3.5% of participants), except for one study in which 25% of participants in the placebo arm required rescue therapy [22]
Child And Adolescent Psychiatric Clinics Of North America, 32 (2), 469494
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