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Advocates have also correctly noted that there isnt a single other medicine where Medicare considers the cost of a drug relative to its potential savings in determining coverage but maybe Medicare should start doing so

Although adenosine deaminase is widely distributed in mammalian tissues, highest levels are found in lymphoid tissue: levels in circulating T cells (particularly in T cell lymphoblastic leukemia) are higher than those in B cells

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World J Gastroenterol 21(41):11552 Kopp M, Morisset R, Rychlik M (2017) Characterization and interrelations of one-carbon metabolites in tissues, erythrocytes, and plasma in mice with dietary-induced folate deficiency

The working principle is shown in Figure 5