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5 Challenges and future directions Despite compelling mechanistic insights and promising early-phase interventions, there are several challenges in translating perioperative mitochondrial immunomodulation into standard clinical care: 5.1 Timing and deliverability Many mitochondrial-protective strategies are highly time-sensitive

Analysis of the gut microbiome revealed beneficial bacteria was significantly enriched, while the bad bacteria significantly decreased

Some non-GLP-1 medications show efficacy primarily for short-term use (12 weeks or less), while others support longer-term management

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Clinical effectiveness of semaglutide on weight loss, body composition, and muscle strength in Chinese adults

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