Long-term GH elevation also carries theoretical cancer concerns, as GH and IGF-1 can promote cell growth
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Early clinical trials on use of long-acting amylin analogs as adjuncts to optimized insulin therapy in type 1 diabetes have shown reduction in HbA1c levels of 0.4-0.7 percentage point and weight loss of 3-6 kg when added to optimized insulin therapy, and the convenience of once-weekly administration is especially significant compared to the 3 times/day injections of pramlintide, which limited the use of first generation amylin analogs
Modifications of active site thiol groups by two redox-dependent aberrant post-translational modifications, S-glutathionylation and S-nitrosylation, lead to inactivation of the normal enzymatic activity of PDI (Walker et al., 2010)
Summary: POTS after bariatric surgery can develop due to reduced blood volume, nutritional deficiencies, and deconditioning following procedures such as Roux-en-Y gastric bypass or sleeve gastrectomy
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