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MGMT inhibition in ER positive breast cancer leads to CDC2, TOP2A, AURKB, CDC20, KIF20A, Cyclin A2, Cyclin B2, Cyclin D1, ER and Survivin inhibition and enhances response to temozolomide
But the starting protocol is almost always daily
The drugs mechanism of action is also unique
doi: 10.1016/S0140-6736(06)68073-2 14 VahratianALinJ-MSBertolliJUngerE
S.BrondenA.DalsgaardN
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