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If fatigue emerges, biomarker testing and genetic context can help distinguish between expected metabolic adjustment and treatable nutritional or metabolic causes, informing whether dose adjustment or supplementation is warranted
For example, individuals with higher oxidative stress or chronic health issues may require higher doses
Due to NMDA receptor hypofunction, there is reduced NMDA receptor signalling in schizophrenia, which leads to a disruption of excitation monitoring, and thus GABAergic neurons respond as if excitatory transmission is insufficient
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These may include nausea, vomiting, diarrhoea and constipation, particularly as the body adjusts to changes in appetite and digestion
Typically, 1-2 times per week for 4-6 weeks is most common
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