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Cross-trial comparisons suggest retatrutide produces greater mean weight loss than semaglutide, though tolerability profiles are broadly similar
If the change is being advised due to mild common side effects, like constipation or bloating, a longer interval to wait may be advised, such as waiting closer to a month before starting a new GLP-1 agonist until all adverse effects have resolved
It is often more of a shrug than a recoil
Monitoring Vitamin B12 During Retatrutide Treatment Baseline serum B12, full blood count, and folate should be measured before starting retatrutide
Sources: Veniant et al., Nat Metab, 2024
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