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The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis
Jiang T, Yin F, Yao J, Brinton RD, Cadenas E
It does not directly stimulate fibroblast proliferation under normal culture conditions, but substantially increases fibroblast survival under hydrogen peroxide-induced oxidative stress acting as a cytoprotective enhancer of the endogenous repair response rather than a direct mitogenic agent
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Boosts The Immune System
Rather than daily injections, the protocol requires a heavier 2.5 mg systemic dose injected twice per week
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