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Strategic Implications If validated in prospective randomized trials, GLP-1 receptor agonists could: Represent an adjunctive strategy in obesity-associated asthma Expand the therapeutic footprint of GLP-1s beyond metabolic disease Influence treatment guidelines in high-BMI asthma populations Given the rapid adoption of GLP-1 therapies globally, further investigation into respiratory benefits could have significant clinical and commercial implications

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Going above this windoweither by taking too much of one drug or combining it with another similar drugdoes not lead to better health outcomes

Plasma folate and cobalamin were determined by microbiological assays using Lactobacillus casei (Molloy and Scott 1997) and Lactobacillus leichmannii (Kelleher and Broin 1991), respectively

However, dedicated kidney outcome trials for GLP-1 receptor agonists remain limited, and further long-term studies are needed to better define their role in CKD management

Methods A non-systematic literature search was performed on PubMed using as search terms (acetyl-l-carnitine OR L-acetylcarnitine OR ALCAR) in conjunction with one of the following: nerve damage, neuropathy, peripheral neuropathy, radiculopathy, neuropathic pain, diabetic polyneuropathy, chemotherapy-induced polyneuropathy, carpal tunnel syndrome, Fabry disease