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Glucagon-like peptide-1 and blood pressure in young and healthy adults from the general population
However, the retrospective design carries inherent limitations
Besson, A
[Clinical benefits after soluble dietary fiber supplementation: a randomized clinical trial in adults with slow-transit constipation]
GLP-1 receptor role as a negative costimulatory mechanism, mitiagting alloimmune responses
Their half-lives are 13 hours (LIRA) and 7 days (SEMA), allowing for daily and weekly subcutaneous administration, respectively, thanks to the structural modifications introduced.5,10 Effects on obesity and glycaemic control Both LIRA 3 mg and SEMA 2.4 mg have demonstrated a strong appetite-suppressing and satiety-promoting effect, as well as a delaying effect on gastric emptying.11,12 The SCALE programme highlighted the efficacy of LIRA 3 mg in reducing body weight and waist circumference13 and confirmed a reduction in HbA1c levels in individuals with diabetes, along with a decreased progression from prediabetes to diabetes after three years of treatment14 (Table 1)
