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In immunocompromised pregnancies that have rendered pregnancy complications, a supraphysiological dosage of melatonin has been shown to reverse the adverse effects of these complications for both the mother and the fetus (34, 86)

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Additionally, this use is off-label, and current evidence is limited, inconsistent, and not approved by major regulatory authorities such as the U.S

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doi: 10.1016/j.postharvbio.2020.111249 7 BozzoG