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Clinical studies show efficacy at concentrations as low as 0.01 nM, with optimal results at 1100 nM (Maquart et al., 2015)
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These hybrid nanoparticles overcome cisplatin resistance by dephosphorylating the PI3K/AKT/mTOR signaling pathway and polarizing M2 macrophages toward the M1 phenotype [212]
& Mason, M
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