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In LEADER and SUSTAIN 6, the GLP-1 receptor agonist liraglutide was associated with an ARR of 1.5% and an HR of 0.78 (95% CI 0.67, 0.92) for new or worsening nephropathy [63], and semaglutide demonstrated an ARR of 2.3% and an HR of 0.64 (95% CI 0.46, 0.88) for new or worsening nephropathy [48]

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D.PacoldM

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However, overreliance on these chemicals has increased the risk of, and directly contributed to, the emergence of insecticide resistance in several insect pest species 8