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Consistent with these biological effects, data from a large population-based cohort in Taiwan showed that initiation of GLP-1RAs, compared with insulin, was associated with a significantly lower incidence of HCC (HR = 0.47, 95% CI: 0.360.61) (Yang et al., 2024)

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These may be due to defective DNA synthesis inhibiting replication in a site with a high turnover of cells

Biguanides exert antitumoral actions in pituitary tumor cells through AMPK-dependent and -independent mechanisms

Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways

In CKD, this balance can be disrupted, leaving people with low calcium levels and an increased risk of osteoporosis or fractures