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2 CKD confirmatory secondary endpoints Significant 18% RRR of MACE with Ozempic 2 For adults with T2D and CKD, for a confirmatory secondary endpoint: Time to first occurrence of MACE (CV death, nonfatal MI, or nonfatal stroke) vs placebo when both were added to standard of care 1,2 Time to first MACE 1-3,w-z 1-3,w-z w Cumulative incidence estimates are based on time from randomization to first EAC-confirmed MACE with non-CV death modelled as a competing risk using the Aalen-Johnson estimator

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Dose-dependent hepatoprotective effect of emodin against acetaminophen-induced acute damage in rats

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De La Torre RI, Garber AK, Mietus-Snyder ML, Tran CT, Madsen K, Orrell-Valente JK, Bostrom AG, Bacchetti P, Lustig RH: Predictors of efficacy of a biochemically-based pediatric weight management program