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Diabetes Care 44(10):22312237

Side Effects and Precautions Common side effects include: Dry lips and dry skin Peeling or flaking of the face Nosebleeds Headaches Muscle or joint pain Photosensitivity Serious but rare side effects may involve: Elevated cholesterol or liver enzymes Mood changes Vision changes Gastrointestinal symptoms Birth defects (if used during pregnancy) Important precautions: Monthly lab tests (CBC, liver enzymes, cholesterol, triglycerides) are required Women must commit to pregnancy prevention programs (e.g., iPLEDGE in the U.S.) Avoid alcohol, Vitamin A supplements, and tetracycline antibiotics during use Do not donate blood during and for at least 1 month post-treatment Use moisturizer and SPF daily to prevent dryness and sun sensitivity Store capsules in a cool, dry place away from direct sunlight Treatment Duration and Results Patients typically undergo a treatment course of 4 to 6 months depending on dosage and skin response

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Focus on a Balanced Diet A balanced diet is one of the most effective ways to manage weight

For constipation, osmotic or stimulant laxatives may be used when dietary measures are insufficient, whereas loperamide or probiotic supplementation may be considered for persistent diarrhea

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