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In contrast, while the dose-response relationship between -cell responsiveness to glucose (expressed as the slope of the linear relation between insulin secretion rate and the glucose concentration) and GLP-1 levels in circulation is partially impaired a phenomenon referred as GLP-1 resistance (62) a therapeutic infusion of GLP-1 at a pharmacological dose can restore -cell insulin secretion responsiveness to glucose levels comparable to those observed in nondiabetic individuals (62)

Patients with a history of DKA: Individuals who have previously experienced DKA are at particularly high risk for recurrent episodes

Get moving: Recommend at least 150 minutes of moderate-intensity aerobic activity or 75 minutes of vigorous-intensity aerobic activity per week, along with muscle-strengthening activities on two or more days per week

Research Support: Boehringer-Ingelheim, AstraZeneca, Janssen, Merck Research Grant (Investigator)

A 6-week wait burns about $217 before the first dose arrives

The treatment plan will be discussed after consultation with our experts