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There is no evidence that doses above 500mcg produce proportionally better results, and clinical trials using 1mg daily did not dramatically outperform lower doses

More severe side effects are rare but can include an allergic reaction or the development of blood clots

The irony, as you point out, is that this same rigidness does not apply to other medications that can be prescribed in a more flexible manner

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However, as with any medical treatment, some people may experience mild side effects after receiving a B12 shot