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These cell states exhibit reduced proliferation, increased resistance to apoptosis, and decreased immunogenicity, collectively enabling survival during cytotoxic or immune-based therapies

Most commonly, this means insulin through multiple daily injections or an insulin pump, though some providers use metformin as an adjunct since its generally considered safe in pregnancy

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Corticosteroids play a unique role in the treatment of AMD by inhibiting the pro-angiogenic effects of inflammatory cytokines and targeting extracellular components of choroidal neovascularization [155], such as inflammatory cells and fibroblasts

doi:10.1111/jdv.13752