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EXamination of cArdiovascular outcoMes with alogliptIN versus standard of carE in patients with type 2 diabetes mellitus and acute coronary syndrome (EXAMINE)

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Semaglutide works by mimicking the GLP-1 hormone to regulate blood sugar and reduce appetite, while retatrutide mimics three hormonesGLP-1, GIP, and GCG to potentially offer more comprehensive benefits for weight loss, blood sugar control, and metabolism

Lancet 402(10401):529544 Clinical trial.gov [Home page in Internet] A study of retatrutide (LY3437943) in participants with obesity and cardiovascular disease (TRIUMPH-3)

Moreover, the occurrence of premotor gastrointestinal symptoms, which may precede Substantia Nigra (SN)-associated motor symptoms, further supports the concept of pathological spread (Ross et al., 2012)

However, those results are from a controlled environment