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The Multi-Log Dosing Window : A landmark study investigating Achilles tendon healing in rats demonstrated that the therapeutic benefit, measured by improved biomechanical strength and functional recovery, was statistically equivalent across doses spanning six orders of magnitude: from 10 micrograms per kilogram (mcg/kg) down to 10 picograms per kilogram (pg/kg) [4]

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However, after we added a bacterial-type selenocysteine insertion sequence element to the open reading frame we successfully expressed TGR, using the strategy previously employed for production of mammalian TrxR [14,15]

Y.MouZ.et al (2014)

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