mechanism of glp 1 GLP-1 glp-1_analogs [TUSOM | Pharmwiki]

Description of exendin-3(939) amide, a specific exendin receptor antagonist

Thompson et al

Body weight and food intake were measured daily, and the rats were euthanized by cardiac exsanguination under deep anesthesia (using a mixture of medetomidine, midazolam, and butorphanol) to obtain skeletal muscle (gastrocnemius) samples on day 15 of treatment initiation

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But unlike the naturally occurring version, which breaks down within a couple of minutes, lab-made GLP-1s are engineered to remain active for up to a week