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The rationale is that bioregulators aim to restore optimal gene expression patterns rather than provide continuous pharmacological effects

Randomization was conducted using an interactive web response system, assigning participants in a 6:1 ratio to one of several treatment arms: once-weekly subcutaneous Cagrilintide administered in doses of 0.3, 0.6, 1.2, 2.4, or 4.5 mg, once-daily liraglutide 3.0 mg, or a volume-matched placebo

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It works through nitric oxide modulation, VEGF-driven angiogenesis, and the FAK-paxillin cell migration pathway