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GLP-1 secretion itself is stimulated in response to food intake ( GLP-1 was discovered in 1981 when it was isolated from the pancreatic islet of anglerfish

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Despite the thermodynamically highly favorable reverse reaction, PfGrx C88S (S 2 ) reacted very slowly with roGFP2 WT (SH) 2 most likely due to the instability and high energy of the Grx(SSR) intermediate

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This assertion is backed by some early animal research

N Engl J Med 316:971977