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doi: 10.3389/fonc.2022.913669 Received 06 April 2022 Accepted 11 May 2022 Published 03 June 2022 Volume 12 - 2022 Edited by Jianming Li, Soochow University, China Reviewed by Yang Li, Shanghai University of Traditional Chinese Medicine, China

ASS1 expression has been reported to be decreased or even abolished in many cancers (Dillon et al., 2004), especially in malignant melanoma (Feun et al., 2012), HCC (Delage et al., 2010), and prostate cancer (Kim et al., 2009), which are thought of as arginine-auxotrophic cancers because of the inability to synthesize arginine and resulting susceptibility to arginine-deprivation therapy

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