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It is classified as a Category 2 bulk drug substance by the FDA, which restricts its availability through compounding pharmacies
Side Effects Common side effects Nausea Vomiting Diarrhea Stomach pain Loss of appetite Serious but less common side effects Risk of pancreatitis Gallbladder issues (gallstones, inflammation) Kidney problems (from dehydration due to vomiting/diarrhea) Potential increased risk of thyroid C-cell tumors (based on animal studies) Patients should report severe or unusual symptoms to their healthcare provider immediately
The combination of faster appetite suppression and potential nausea can lead some people to eat and drink less than they should in the hours after an intramuscular injection
Downregulation of OCTN2 by cytokines plays an important role in the progression of inflammatory bowel disease
Elevated tumor necrosis factor- levels are responsible for the development of cancer cells and increased mortality
In 2023, the American Society of Anesthesiologists advised holding all GLP-1RA drugs for a day (if taken daily) or a week (if taken weekly) before surgery
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