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Pyruvate occupies a central branch point in the energy metabolism of H
While under oxidative stress, the selective autophagy receptor and ubiquitin (Ub) sensor p62 binds to Keap1 and interferes with the Keap1NRF2 interaction when exposed to ferroptosisinducing agents [24], thus the NRF2 protein is stabilized and triggers downstream signal transduction to dampen the ferroptosis sensitivity of cells [25] [26, 27]
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