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In a separate apoptotic pathway, TNF-induced cell death involves early caspase-9 activation that occurs independently of cytochrome c

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Liver-metastatic breast cancer cells display a distinct metabolic reprogramming characterized by accumulation of glucose-derived lactate and reduction in the TCA cycle and OXPHOS (138)

Lipoic acid was found to effectively slow disease progression when administered either orally (87), intraperitoneally (88), or subcutaneously (89) to mice with experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis

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