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In addition to direct DNA damage, free radicals also influence carcinogenesis through the modulation of cellular signaling pathways
One-carbon metabolism and the transsulfuration pathway contain many allosteric interactions by which substrates in one part of the pathway affect the activity of distant enzymes
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Curr Opin Pharmacol 7:398403 Giordano G, White CC, McConnachie LA, Fernandez C, Kavanagh TJ, Costa LG (2006) Neurotoxicity of domoic acid in cerebellar granule neurons in a genetic model of glutathione deficiency
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