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While mtROS generation serves as a signaling cue for immune activation, excessive accumulation leads to oxidative stress, mtDNA damage, and mitochondrial permeability transition

How do GLP-1 analogs confer health benefits

Serious but rare adverse effects include pancreatitis, gallbladder disease, and diabetic retinopathy complications requiring monitoring

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For instance, a large network meta-analysis showed that SGLT-2 inhibitors reduced hospitalization for HF and renal composite outcome more than GLP-1RA [15], and that in patients with cardiovascular disease, SGLT-2 inhibitors show significant reduction in both heart failure (HF) hospitalizations and mortality for patients with HF and reduced ejection fraction [16]

Metformin and diarrhoea