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Generally, most GSTs are upregulated rather than downregulated during the resistance reaction, as confirmed in pepper leaves infected with Obuda pepper virus ObPV ( Arabidopsis thaliana ( Beta vulgaris and beet necrotic yellow vein virus-BNYVV interactions ( - CGMMV ( GSTU4 downregulation caused a significant reduction in the accumulation of barley mosaic virus (BMV) and PVX in a specific host

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Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)

doi: 10.3389/fmed.2023.1124275 Received 14 December 2022 Accepted 27 February 2023 Published 22 March 2023 Volume 10 - 2023 Edited by Ana Sandoval-Rodriguez, University of Guadalajara, Mexico Reviewed by Angelo Armandi, University of Turin, Italy

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In www.ncbi.nlm.nih.gov