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In addition, the increased expression and activity of NOX and xanthine oxidase and NOS becoming uncoupled and structurally unstable also lead to increased ROS production [8]

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10.1089/ars.2006.8.813 Antioxid Redox Signal

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Based on the amount of GSH in the lysate, we calculated the GSH concentration assuming an averaged HeLa/HT1080 cell volume of 4,000 m 3 (refs 15, 51, 52)

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