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The phase 2 results published in The New England Journal of Medicine in 2023 were promising, but phase 3 data which will involve thousands of participants followed for longer periods is required before approval

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116 Exocytosis from islet alpha cells was blocked by a GCGR antagonist after glucagon administration

Metabolic disorders like type-2 diabetes are highly comorbid with neuropsychiatric disorders, and motivational symptoms are postulated to play a mediating role in the relationship [9]

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