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Tirzepatide's appetite suppression makes hitting protein targets challenging

As Janumet is a combination drug, its action extends beyond that of sitagliptin (which makes up Januvia)

Brief receptor occupancy with short-acting GLP-1 RAs could explain the transient effect on HR, while prolonged receptor occupancy could explain the more pronounced HR effect observed with some long-acting GLP-1 RAs

Its levels decline after age 60, and lower levels are linked to faster cognitive decline, while higher levels are associated with reduced risks of heart disease and overall mortality, suggesting its importance for healthy aging and disease prevention

Weight loss from GLP-1s can restore ovulation, which may lead to unexpected fertility (20)

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