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Efficacy differs measurably in trials, with semaglutide showing up to about 15% average body weight reduction over extended study periods versus roughly 9% average weight loss for liraglutide at 12 months

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Collective data from major clinical trials have shown that treatment with a DPP-4i improves glycemic control by increasing insulin secretion from islet cells, lowering levels of HbA1c, reducing adipocyte size, and suppressing inflammation [47,48,49,50,51]

doi: 10.3389/fbioe.2023.1193454 Received 24 March 2023 Accepted 31 May 2023 Published 15 June 2023 Volume 11 - 2023 Edited by Michel Eppink, Wageningen University and Research, Netherlands Reviewed by Mirna Alejandra Gonzlez-Gonzlez, Tecnolgico de Monterrey, Mexico Christos S