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Studies suggest 10-20 times higher tissue concentrations compared to topical application of equivalent amounts

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Where supplements fit in the picture Supplements that increase the fermentable substrate delivered to the colonprebiotic fibers such as inulin, resistant starch powders, or specialized propionate deliveryhave shown modest changes in gut-derived hormones in controlled human studies

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Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression

doi:10.1016/j.nutres.2020.08.008