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Current NICE guidance (NG28 for type 2 diabetes, TA875 for semaglutide 2.4mg, and TA664 for liraglutide 3.0mg) does not include inflammatory conditions as indications

In addition to demonstrating in vitro cAMP activity at human and mouse GLP-1R in transfected CHO and in the mouse MIN6 insulinoma cells, MEDI4166 induced glucose-stimulated insulin secretion in INS1 -cells and displayed a desirable profile in rodent disease models

BFF has received grants from Esteve and AstraZeneca and consultancy or speaker fees or travel support from AstraZeneca, Bayer, Menarini, Novo-Nordisk, Boehringer, Lilly, Amgen and Mundipharma

This link to the blood vessel risk factors is very important when we try to understand how it is connected to some medications