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4.1 Limitations and implications for practice This meta-analysis has several limitations that should be considered when interpreting the findings

Elevated NNMT is linked to: Reduced NAD+ availability Slower mitochondrial function Increased fat storage efficiency Higher risk for insulin resistance By reducing NNMT activity, 5-Amino-1MQ allows the body to maintain higher NAD+ levels, which can support better mitochondrial performance, improved fat oxidation, and more balanced energy metabolism

Future research and clinical trials will be crucial in determining its potential for broader medical applications and its place in therapeutic protocols

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PMID 16916826

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