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One of the key trials, SUSTAIN 6, found that semaglutide lowered the risk of major cardiovascular events in high-risk patients with diabetes

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Based on the clinical evidence: most patients lose 3 to 4% of body weight in their first month, 10% by month three, and 15% or more over their first year of treatment when combining semaglutide with lifestyle changes

During traditional dieting, the body responds to caloric deficit by increasing ghrelin (the hunger hormone), decreasing leptin (the satiety hormone), reducing thyroid hormone output, and increasing cortisol