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(Recommendations to limit Nausea: Eat bland, low-fat foods, like crackers, toast and rice

These cytokines damage vascular ECs, leading to endothelial dysfunction, reduced nitric oxide (NO) secretion, and increased endothelin-1 (ET-1) production

Weekly to biweekly infusions are typically recommended to maintain optimal vitamin levels

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This titration schedule helps minimise gastrointestinal side effects, which are common during initiation