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Additionally, exendin-4 treatment mitigated high glucose-induced mitochondrial dysfunction, as evidenced by reduced expression levels of mitochondrial function-associated genes mitochondrial calcium uniporter (MCU) and uncoupling protein 3 (UCP3), as well as the mitochondrial fission-related gene dynamin-related protein 1 (DRP1) [79]
In clinical trials, participants achieved an average of 8.5 percent body weight loss by week 24 at the 8 mg dose, with results accelerating through week 48
Now, why GLP Ones become part of this conversation is because these medications have strong evidence for improving insulin sensitivity
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