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The practical answer is to hold at a dose that gives comfortable results rather than always climbing toward the maximum

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Kane, MD, MPH , at Duke University School of Medicine and Dariush Mozaffarian, MD, DrPH, FACC , at Tufts University and Tufts Medical Center

Administration and Treatment Programs Both semaglutide and tirzepatide are administered once per week via subcutaneous injection typically in the abdomen, thigh, or upper arm

Further reading: Retatrutide vs Mounjaro The main caution is that retatrutide is still investigational

Tirzepatide users face iron deficiency risk through two pathways