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doi:10.1007/s12010-011-9436-3 Chen J, Xie L, Cai J, Yang C, Duan X (2013) Enzymatic synthesis of glutathione using engineered Saccharomyces cerevisiae

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The most dramatic result (mice returning to a body composition indistinguishable from lean age-matched animals) came from combining the inhibitor with a low-fat diet switch, and that study did not include a drug-alone arm