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Stomach discomfort General abdominal discomfort affects about 20% of patients

The lowest dose that provides desired metabolic effects while preserving ability to eat adequately represents the optimal choice

While side effects typically peak during the first 48 weeks, most patients adapt over time, with appetite regulation persisting as initial discomfort resolves

A potential unifying feature that enhances susceptibility among those with each of these conditions is an elevation in systemic inflammation, which leads to a greater viral load with the potential for a cytokine storm and increased mortality 3

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