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Oncogene 38 , 47294738 (2019)
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Results Construction of a screening assay using primary cultures of Bdnf-Luc mouse cortical cells We have previously demonstrated that induction of Bdnf transcription could be detected by measuring luciferase activity and in vitro bioluminescence imaging using primary cultures of cortical cells prepared from Bdnf-Luc mouse embryos 19,20
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This allows assessment of how much improvement persists after the peptide clears the system
Development of small-molecule probes that selectively kill cells induced to express mutant RAS
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