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It was first identified in 1973 by biochemist Loren Pickart, who observed that plasma from younger donors caused older liver tissue to resume more youthful metabolic activity

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Moreover, we have demonstrated that low picomolar PregS increases [Ca 2+ ]i and CREB phosphorylation and the frequency of spontaneous excitatory post-synaptic currents (48) (Figures 8, 9)

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doi: 10.1016/j.ymthe.2016.11.020